Formulation of buccal bioadhesive tablet of diltiazem hydrochloride and its evalution

Abstract

Buccal bioadesive tablet containing diltiazem hydrochloride was prepared for treatment of hypertension. Carbopol 974 and hydroxy propyl methyl cellulose K4M were used in combination as a bioadesive polymer. The tablets were assessed for release using a model drug as diltiazem hydrochloride by using in vitro dissolution method. The tablets have shown the significant release of model drug which shows good effect of drug by avoiding first pass metabolism of diltiazem hydrochloride. The tablets were evaluated by using various parameters as weight variation, tablet hardness, drug content, bioadhesion force and swelling index.