Preparation and Characterization of Curcumin based Nanogel for Topical Anti-inflamatory Activity

Abstract

Although there are challenging systems for both local and systemic effects of drugs, transdermal medication administration holds promise. For transdermal medication administration, the duration of a drug formulation's stay in the skin is crucial. Creating a nanogel with smaller particles was the main goal of the current study in order to increase the bioavailability of the anti-inflammatory medication. With the help of an emulsion-solvent diffusion approach and the addition of a gelling agent to create nanogel, curcuminnanosize dispersion is being created in this work. The particle size ranges from 100 to 400 nm, which is a characteristic of the formulation of an anti-inflammatory and anti-arthritic medication called curcumin.According to the results, a glycerol:water (20:80) co-solvent system was chosen because it has a higher permeability coefficient than alcohol:water co-solvent when creating curcuminnanogels using various polymers. In a franz diffusion cell, permeation over a cellophane membrane was carried out using 0.9% w/v sodium chloride as the receptor fluid (1.74 cm2). Eudragit polymer-based curcumin gels have demonstrated higher permeability coefficients. The study's findings indicate that when compared to nanogels made with HPMC and methyl cellulose, those made with carbopol and a permeation enhancer showed superior flow augmentation. It has been determined that curcuminnanogels with carbopol 940 as a gelling agent and Eudragit S-100 as a permeation enhancer have demonstrated superior flow augmentation.