Design of novel oral films as drug delivery system

Abstract

The main aim of research work was to design novel fast dissolving films as a drug delivery system for treatment of severe hypertension and acute cases like angina pectoris. In present research work thin films of antihypertensive drug amylodipin besylate was prepared by using different concentration of polymers, plasticizers and super disintegrants. These prepared films were characterized on basis of thickness, folding endurance, tensile strength and dissolution time. On basis of study it was found that the optimized film dissolves within 60 sec. So the drug will dissolve quickly which will increase solubility and hence bioavailability of drugs.