Design and characterization of melt-in-mouth tablets of metoprolol tartarate

Abstract

The purpose of the present research was to compare the effect of superdisintegrants on the Melt-in-mouth property of Metoprolol Tartrate tablets. Metoprolol tartrate is effective β-blocker which is having anti-anginal properties and used in the treatment of myocardial infarction. In the present work Melt-in-mouth  tablets of metoprolol tartrate were prepared by direct compression method using superdisintegrants such as Isapgol husk, sodium starch glycolate and  croscarmellose sodium. Among the formulations the most promising one is F3 containing 12% Isapgol husk with 10% camphor showing 99.45% drug release indicating better drug release and improved bioavailability. So it was concluded that sublimation method along with superdisintegrant addition was excellent method in formulation of Melt-in-mouth tablets of Metoprolol Tartrate which gives quick relief from Myocardial infarction.