Effect of contaminated fish meal diet on estrous cycle, hormones and biochemical changes in ovary and uterus of Rattus norvegicus

Abstract

The aim of the present investigation was to evaluate the adverse effects of consumption of contaminated fish meal diet on estrous cycle, hormones and biochemical constituents in ovary and uterus of Albino rats, Rattus norvegicus. Rats were randomly distributed into five groups (n=6), Group I served as control, while group II, III and IV received combination of fish meal ratios and group V only fish meal diet for 90 days respectively. Result revealed fish meal diet arrested the normal estrous cycle at diestrous phase and reduction in protein, glycogen, and cholesterol in ovary and increase cholesterol content in uterus of experimental groups. Gradual decrease of estrogen indicated the fall of hormonal levels in all experimental groups (p< 0.05) and increase of progesterone led to prolonged diestrous phase. These changes indicates alteration in the physiology of the animal to toxic substance in contaminated fish meal diet which has a negative implication on the reproductive performance of rat.