Quantitative estimation of Ciprofloxacin in marketed formulation by hydrotropic techniques

Abstract

An accurate, precise, sensitive and economical procedure for the determination of ciprofloxacin hydrochloride in tablet dosage form has been developed. In the present investigation, 2.0 M urea solution (hydrotropic solubilizing agents was employed to solubilize, Ciprofloxacin (a poorly water soluble drug) from fine powder of its tablets to carryout spectrophotometric analysis. The result showed that Beer’s law was obeyed in concentration range of 5-50 mg/ml with good linearity (r²>0.99) for both the drugs in both methods. The recoveries were within 98.62 -101.27% for Ciprofloxacin hydrochloride. Precision was good with acceptable limits of detection (LOD) and quantitation (LOQ) for both compounds. The average content of the compound was 101.23 for Ciprofloxacin hydrocloride.The optimized methods showed good reproducibility and recovery with standard deviation of < 1.0% and percent relative standard deviation less then 2.0%.