Combination of Estriol and Vitamin D assists in improving stress incontinence stage

Abstract

In world population, almost one in every group of five female suffers from inability to retain urine . This loss of
urine occurs due to various reasons but main reasons is the age factor, after crossing fifty this conditions comes to
prevail as women are already experiencing pre- and post menopause stage. We selected 120 female mice of age 11-
25 months old for the study. We evaluated the level of vitamin D in all of them by vitamin D ELISA assay kit. 40
mice were clubbed together as they were suffering from stage 1 and other 40 were suffering from stage 2. All of
them were given the dose of estriol (0.005 mg) together vitamin D at (10 I.U/kg) i.p 3 times a week for a period of 6
weeks. More than one-third of mice are now able to retain urine in both the category. In I category where mice were
suffering from stage 1 stress incontinence. Urine loss quantity was reduced 35-50% while coughing and sneezing.
For II category 25% remarkable decrease. Therefore, mice in our study being incapable of retaining urine improved
their body conditions by using a combination of i.p administered estriol and high dosed vitamin D.