Pharmacokinetic and Pharmacodynamic Evaluation of Transferrin Conjugated Polymeric Nanoparticles of Ziprasidone Hydrochloride

Abstract

The development of advanced drug delivery systems can significantly enhance the therapeutic efficacy of drugs with limited bioavailability and brain targeting capabilities. This study focuses on formulating transferrin-conjugated chitosan nanoparticles (Tf-CH-NPs) of Ziprasidone Hydrochloride (ZH) to improve brain delivery and bioavailability. Optimization of chitosan nanoparticles using the Box-Behnken Design, surface modification with transferrin, and subsequent in vitro and in vivo evaluations were performed. Pharmacokinetic and pharmacodynamic studies in rat models revealed significantly improved brain targeting efficiency and therapeutic effects of Tf-CH-NPs compared to non-conjugated nanoparticles and ZH solutions. The study provides a robust framework for developing transferrin-based nanocarriers for effective brain delivery of therapeutic agents.