Preparation and Evaluation of Oral Dispersible Formulation of Amlodipine Beslate

Abstract

The oral dispersible drug delivery system or fast dissolving drug delivery system are specially designed for the drugs which have extensive first pass metabolism and have low dose, for the enhancement of bioavailability. They undergo disintegration in the salivary fluids of the oral cavity within a minute, where they release the active pharmaceutical ingredient. The major amount of the active pharmaceutical ingredient is swallowed orally with the saliva where subsequent absorption takes place in the gastro-intestinal tract. The rapidly dissolving dosage forms are referred by various names by researchers like quick disintegrating, orally disintegrating, mouth dissolve or melt in mouth dosage forms Amlodipine belongs to the dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) which inhibits the Trans membrane influx of calcium ions into the vascular smooth muscle and cardiac muscle. The contractile processes of the cardiac muscle and vascular smooth muscle are dependent on the movement of extracellular calcium ions into cells through specific ion channels. Amlodipine inhibits the calcium ion influx across cell membranes selectively, with the greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects can be detected in vitro but such effects have not been seen in intact. Salient Features of Oral Dispersible Drug Delivery System
 Ease of administration for patients who are mentally ill, disabled and uncooperative.
 No need of water to swallow the solid dosage form.
 Quick disintegration and dissolution of the dosage form.
 Drugs absorbed from the mouth, pharynx and esophagus as the saliva passes down into the stomach. In such cases bioavailability of the drug is increased
 An increased bioavailability, particularly in cases of insoluble and hydrophobic drugs, due to rapid disintegration and dissolution of these tablets.