Formulation and Characterization of Acebrophylline andMontelukast sodium Bi-layers tablets Antiasthamatic drug

Abstract

Oral drug delivery is the most preferred and convenient option as the oral route provides maximum active surface area among all drug delivery system for administration of various drugs. In present work, Bilayer tablet of Acebrophylline (Sustain Release) & Montelukast Sodium (Immediate Release) were prepared by direct compression method. All trials of Acebrophylline & Montelukast Sodium and were subjected to precompression, post compression & in vitro drug release study. Bilayer tablet were prepared with passed trials of Acebrophylline & Montelukast sodium (i.e. FP-02) compared with ACEBRO-M (Marketed Product) for its pot compression parameters && in vitro drug release study.