Comparison of Anti-inflammatory Activity of a Bright Red Carotenoid Hydrocarbon Lycopene and Aceclofenac in Rats

Abstract

There are numerous plants which are used in Ayurveda and other traditional system of medicine but their claim is not yet evaluated scientifically in Laboratory Animals. Present study was intended for the “ Comparison of Anti-inflammatory Activity of a Bright Red Carotenoid Hydrocarbon Lycopene & Aceclofenac in Rats” to confirm Ethnomedical claim made by traditional health practitioners. Lycopene was obtained from the tomatoes from local market of Indore. Fruits (Tomatoes) were processed for juice extraction in ethanol. Ethanolic extract was evaporated using rota evaporator and stored at cool and dry place. Extract was Orally Administered in rats (400/600 mg/kg) and evaluated using Plethysmometer. Aceclofenac (10 mg/kg) was taken As A standard drug. Significant anti-inflammatory activity comparable with standard dose of aceclofenac was observed. This confirms ethnomedical claim of some workers regarding anti-inflammatory activity of the plant.