Transdermal Drug Delivery System: A Tool for Novel Drug Delivery System

Abstract

The human skin is a readily accessibl esurface for drug delivery. Skin of an average adult body covers a surface of approximately 2m2 and receives about one- third of the blood circulating through the body. Over the past decades, developing controlled drug delivery as become increasingly important in the pharmaceutical industry. The human skin surface is known to contain, on anaverage, 10-70 hair follicles and 200-250 sweat ducts on every square centimeters of the skin area. It is one of the most readily accessibl eorgans of the human body. There is considerable interest in the skin as a site of drug application both for local and systemic effect. However, thes kin, in particular the stratum corneum, poses a formid able barrier drug penetration there by limiting topical and Transdermal bioavailability. Skin penetration enhancement techniques have been developed to improve bioavailability and increase the range of drugs for which topical and Transdermal delivery syste(NDDS).