Formulation and Evaluation of Dexlansoprazole Floating Tablets

Abstract

The purpose of this research was to prepare a Dexlansoprazole GastroRetentive Drug Delivery System. Dexlansoprazole with gas propellant
with controlled release can be developed to increase the time of gastric
permanence and therefore increase its bioavailability. The formulated
floating tablets have given satisfactory results for various postcompressive parameters such as hardness, friability, thickness, weight
variation and uniformity of the content. Sodium bicarbonate has a
predominant effect on the buoyancy delay time, while chitosan has a
predominant effect on the total flotation time and drug release. Carbopol
also shows a significant effect in drug release. Sodium alginate and
xanthan gum gave additional adhesive properties and helped maintain the
integrity of the tablet. The swelling index has a significant effect on drug
release.
Formulations F2 and F4 showed a higher rate of swelling than others. In vitro release rate studies showed
that maximum drug release was observed in F2 and F2 formulations for up to 12 hours. TLC studies
revealed that there was no interaction between dexlansoprazole and the polymers used. The data obtained
from in vitro dissolution studies were fitted in different models viz. zero order, first order and
Korsemeyer’s equation. The zero order plots were found to be fairly linear as indicated by their high
regression values (r2 = 0.979 to 0.996). From the study it is evident that the floating tablets based on
Dexlansoprazole with gas propellant with controlled release can be developed to increase the time of
gastric permanence and therefore increase its bioavailability.