Microencapsulation technique by solvent evaporation method (Study of effect of process variables)

Abstract

The preparation of microsphere by solvent evaporation method has been studied extensively to prepare a microsphere using biodegradable polymer. The properties of biodegradable microsphere of poly (lactic acid) (PLA) and (acid lactic- co-glycolic) (PLGA) have been extensively investigated. The encapsulation of highly water soluble compounds including proteins and peptides is providing challenges to the pharmaceutics person. The successful encapsulation of such entities requires high drug loading in the microsphere, prevention of protein degradation by the encapsulation method, and predictable release of the drug compound from the microsphere. Multiple emulsion techniques and some other innovative modifications have been made to the conventional solvent evaporation process. A several process variable affecting the quality of product has been studies in this review.