Comparative evaluation of chemical equivalence of some commercially available brands of Gatifloxacin tablet

Abstract

This study was undertaken with the objective of evaluating of six brands of Gatifloxacin tablets and the chemical equivalency with the use of an analytical method, which will be easy to use, accurate, reproducible, simple, and inexpensive. The chemical equivalence of six brands of Gatifloxacin tablets were assessed through the non-aqueous titration procedure with the use of crystal violet solution indicator. The non-aqueous titrimetric procedure showed that the excipients did not affect the procedure; with three brands having values within the range specified. While the remaining three brands gave lower values. The non-aqueous titrimetric procedure used in this study is simple, inexpensive, and easy to use and could be used in routine monitoring of the quality of Gatifloxacin tablets, especially in the absence of high technology equipments that are not easily available in most developing countries.