Synthesis and anti microbial activity of novel 5-substituted pyrrolo-β-carbolines

Abstract

A series of 5-substituted pyrrolo β-carbolines  have been synthesized via Bischler-Napieralski reaction. The structures of these compounds have been established by various analytical methods. All the  compounds have been evaluated for anti microbial activity against two Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) , two Gram negative bacteria (Escherichia coli and  Pseudomonas aeruginosa) and two fungi(Candida albicans and Aspergillus niger) by Disc diffusion method. The results of anti-bacterial screening reveal that the compounds possess antibacterial activities to certain extent and significant antifungal activities.