A study on the blood lactate level in Type II diabetic patients on oral antidiabetic drugs

Abstract

This study aimed to evaluate the change in blood lactate level in Type II diabetic patients on oral anti diabetic drugs –sulphonylurea & biguanides has been conducted in the Institute of pharmacology, Madurai Medical College Madurai after obtaining ethical clearance.70 newly diagnosed without any prior treatment and without any complications Type II Diabetic patients were selected. After getting informed consent they are treated with the drugs. Blood estimation was done before & one month after the therapy. The studies reveal that biguanides produce increase in blood lactate level. Biguanides to be given with caution in patients prone for hypoxia.