A Review on Topical Film Forming Spray

Abstract

Some disadvantages of conventional medication formulations for topical application include low permeability, poor adhesion to skin, and reduced patient compliance. These new drug delivery methods intended for topical administration are called topical film forming systems. the skin, which clings to the body to create a thin, translucent layer that allows active ingredients to be delivered to bodily tissue over an extended period of time. The current study's goal was to develop and assess spray-based film-forming techniques for bacterial and fungal diseases. Film-forming polymers were added to the solvent system to make the formulation, and then the plasticizer and medication were added. Clotrimazole combined with ethyl cellulose and Eudragit RS 100 as film formers, PEG 400 and PEG 5000 as plasticizer, to create two distinct film-forming spray solutions using acetone and ethanol as the solvent combination. Using Design Expert 13 software, 32 factorial design was used for optimisation. A number of factors, including viscosity, drying time, spray angle, film formation time, drug release, antimicrobial activity, pH, and water washability, were assessed for the optimised formulations.Film-forming methods offer advantages such as controlled release, lower dosage, water resistance, preventing secondary infections, and decreased wiping risk, which will make them an excellent platform for topical treatment against a variety of skin illnesses. in contrast to the traditional semisolid dosage forms, such as contact-free application, peel-out, etc.