Dissolution enhancement of Fenofibrate tablet through Solid dispersion technique by Kneading method using various ratio of Poloxamer-188Fenofibrate is a poorly water soluble drug of fibrate class, mainly used in patients at risk of cardiovascular disease

Abstract

Fenofibrate is a poorly water soluble drug of fibrate class, mainly used in patients at risk of cardiovascular disease in the treatment of hypercholesterolemia and hypertriglyceridemia. Hence this article investigates enhancement of dissolution profile of fenofibrate through the preparation of solid dispersions by kneading method using poloxamer-188 as hydrophilic carrier. Fenofibrate tablets were prepared from solid dispersion containing three different ratios of poloxamer-188; 1:1, 1:3 and 1:5. In vitro drug release studies were performed using US Pharmacopeia type II apparatus (paddle method) in 900 ml distilled water containing 0.75 % wt/v sodium lauryl sulfate  at 100 rpm for 50 minutes. UV-Visible Spectrophotometric method was selected for assay as well as dissolution studies at λ_max 290 nm. The drug dissolution studies followed zero order, first order and Korsmeyer-Peppas release kinetics. Statistically significant improvements were found among the drug release profile from all the solid dispersion tablets. The formulations containing drug poloxamer at a ratio of 1:3 exhibited superior dissolution (99.47%) than all other as well as pure drug (24.58%). Thus solid dispersion technique using poloxamer-188 can be successfully used for improvement of dissolution as well as bioavailability of fenofibrate.