Synthesis, Characterization and Antibacterial activity of halogen dcerivatives1, 3, 4- thiadiazole

Abstract

1,3,4-thiadiazole compounds are under come the category of heterocyclic
compounds. Some new 1,3,4-thiadiazole compounds has been synthesize
to use halogens like chlorine, fluorine etc. Initially 4-flouro benzoic acid
and thiosemicabazide has been taken in the presence of POCl3. An
intermediate product was yield named 5-(4-Fluoro-phenyl)-
[1,3,4]thiadiazol-2-ylamine then with the help of halogens derivatives
two coumpound synthesized i.e. 4-Fluoro-benzylidene)-[5-(4-fluorophenyl)-[1,3,4]thiadiazol-2-yl]-amine and 4-Chloro-benzylidene)-[5-(4-
fluoro-phenyl)-[1,3,4]thiadiazol-2-yl]-amine. Both compounds
characterized by IR, Mass & NMR then they were send to evaluate
antibacterial activity.