A Review on Novel Vesicular Drug Delivery System: Transfersomes

Abstract

In novel drug delivery systems, transdermal route is considered most safe and
effective due to several advantages such as predictable and extended duration of
action, avoidance of first pass metabolism, lesser side effects etc. However it has
also got certain limitations like incompetence to overcome barriers of stratum
corneum, unable to transport larger molecules and many more. To overcome all
these problems, transfersomes came into existence as they possess the quality of
other transdermal drug delivery systems but at the same time can also cross the
barrier with ease. These transfersomes being an ultradeformable vesicle and
elastic in nature can squeeze itself through a pore which is many times smaller
than its size owing to its elasticity.
Hence among various vesicular systems, transfersomes have gained enormous
importance in the last decade for sustained and targeted drug delivery. Knowing
the potentiality of this novel vesicular drug delivery system, main focus has been
given in this article towards reviewing all key aspects of a transfersomes through
various literatures, along with its applications for delivery of various substances
such as herbal drugs, proteins, NSAID’s etc.