Buccal Drug Delivery System

Abstract

The utilization of medications to treat illness is entering a new phase in which an increasing variety of cutting-edge drug delivery techniques are being used. The oral mucosa has a number of characteristics that make it an appealing location for drug administration but also present a number of challenges for researchers in terms of effective and efficient therapeutic active agent delivery. Nevertheless, a number of obstacles were solved with the invention of novel distribution strategies.High blood flow, quick recovery, avoiding the hepatic first-pass impact, and pre-systemic elimination in the gastrointestinal tract are just a few benefits of oral mucosa delivery. However, the main drawbacks of buccal delivery include its relatively small surface area and considerable drug loss from swallowing and salivary flow. For distribution into and/or across the oral mucosa, a variety of formulations, including sprays, pills, mouthwashes, gels, pastes, and patches, are now employed. Numerous formulations for buccal drug delivery systems have been created over the past 20 years, but only a few number have proven successful enough to be approved as medicines. The absence of standardized methodologies to assess the in vitro effectiveness of buccal dosage forms may be one of the primary causes of this poor outcome.The purpose of this study is to explain the advantages of buccal dosage forms and buccal drug delivery, as well as to examine current research and in vitro analysis techniques for buccal dosage forms.