Aquasome- A novel carrier system

Abstract

Aquasomes are three layered self assembling composition with ceramic carbon naocrystalline particle core coated with glassy ceroboise or degradable calcium phosphate monomer crystalline particle coated with glassy pyridoxil-5-phosphate. Subsequently drug/enzymes covalently bonded to outer coating. Aquasomes are spherical 60–300 nm particles used for drug and antigen delivery. Properties like protection and preservation of fragile biological molecules, conformational integrity, and surface exposure made it as a successful carrier system for bioactive molecules like peptide, protein, hormones, antigens and genes to specific sites. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. Aquasome deliver their content through specific targeting, molecular sheiling and slow sustained release process. Aquasome technology represents a patform system for conformational integrality and biochemical stability of bioactives.