Synthesis and screening of some novel 7-Hydroxy 4-Methyl Coumarin derivatives for antipsychotic activity

Abstract

Coumarin derivatives have shown dopaminergic antagonistic activity. In this direction our efforts were devoted to combine 7-Hydroxy-4-Methyl coumarin nucleus with different secondary amines through two carbon spacing to obtain compounds having affinities for both dopamine and 5-HT receptors. All synthesized compounds were evaluated for antipsychotic activity and have shown dopaminergic and 5-HT receptor blocking action.