Formulation and Evaluation of Moxifloxacin Hydrochloride Floating Tablet

Abstract

The tablet was prepared using appropriate procedure n equipments. and
then Post Compression Studies was performed accordingly. The post
compression studies included Hardness Thickness, Friability, Weight
Variation, Floating Lag Time, Floating Time, and Drug Release.the
results of our study clearly indicate that Weight Variation data of the
prepared tablets indicated no significant difference in the weight of the
individual tablet from the average value. Hardness of the prepared tablets
was observed in range of 1.263±0.07 to 1.184±0.05 kg/cm2
. Thickness of
all the tablets was found in the range of 4.16±0.1 to 4.26±0.04 mm.
Friability was found below 1%. The floating lag time was found to be in
range of 15-22 sec. Total Floating Time was found to be in range of 6-7
Hrs. Swelling Index was found to be between 78 to 124%. Drug Release
of FT4 was found to be the good i.e. 94.524%. From results it concludes
that the floating lag time increased as hardness increased and F4 had
better controlled release than the other formulations. So, formulation F4
provides a better option for Controlled release action and improved
bioavailability of Moxifloxacin Hydrochloride Hydrochloride. On the
basis of present study it was concluded that floating tablets of
Moxifloxacin Hydrochloride hydrochloride can increase the gastric
residence time as well as bioavailability and thus better patient’s
compliance can be achieved.