International Journal of Pharmacy and Life Sciences
International Journal of Pharmacy and Life Sciences (IJPLS) ISSN: 0976-7126 Publisher: Sakun Publishing House The International Journal of Pharmacy and Life Sciences (IJPLS) is a peer-reviewed, open-access journal dedicated to the dissemination of cutting-edge research in the fields of pharmacy, life sciences, and allied disciplines. The journal aims to provide a platform for the global scientific community to share innovative research, clinical studies, and technological advancements that contribute to the understanding and improvement of human health and well-being. Scope and Focus IJPLS covers a wide range of topics within the pharmaceutical and life sciences fields, including but not limited to: Pharmaceutical Sciences: Drug discovery, formulation development, pharmacology, pharmaceutics, toxicology, and pharmaceutical technology. Medicinal Chemistry: Molecular pharmacology, drug design, and bioinformatics. Clinical Pharmacy: Drug therapy management, clinical trials, patient safety, and therapeutic outcomes. Biotechnology: Applications of biotechnology in pharmaceuticals, drug production, and health solutions. Pharmacogenomics: Genetic factors in drug response, personalized medicine, and genomics. Pharmacovigilance: Adverse drug reactions, drug safety, and regulatory affairs. Life Sciences and Biotechnology: Molecular biology, biotechnology applications, and biopharmaceuticals. Public Health: Health policy, epidemiology, disease prevention, and public health initiatives. The journal welcomes original research articles, review articles, case reports, short communications, and letters to the editor that contribute to advancing knowledge in these areas. Mission and Vision Our mission is to foster the exchange of high-quality scientific knowledge in pharmacy and life sciences, and to promote collaboration among researchers, clinicians, and policymakers globally. We aim to: Advance Scientific Discovery: Publish original and groundbreaking research that drives advancements in pharmacy, life sciences, and health-related disciplines. Support Innovation and Education: Provide a forum for innovative solutions in pharmaceutical sciences and life sciences, while promoting education and awareness on emerging trends and technologies. Enhance Patient Care: Publish research that directly impacts patient care, pharmaceutical practice, and health outcomes. Global Collaboration: Foster a global platform for scientists and healthcare professionals to collaborate, share knowledge, and solve global health challenges. Editorial Standards and Peer Review IJPLS follows a rigorous double-blind peer review process to ensure that only high-quality, original research is published. All manuscripts are thoroughly reviewed by experts in the relevant fields before they are accepted for publication. Our editorial board comprises respected professionals and thought leaders from academia, industry, and clinical practice who ensure the integrity and scientific quality of each published article. Open Access Policy IJPLS is an open-access journal, meaning that all articles are freely available to researchers, clinicians, and the public worldwide. Our open-access policy ensures that valuable scientific knowledge is accessible to all, promoting wider dissemination and greater impact of the research. Ethics and Integrity The journal adheres to the highest ethical standards in the publication of scientific research. We are committed to promoting transparency, integrity, and honesty in the scientific community. We encourage authors to follow ethical guidelines for research involving human subjects and animals, and we uphold policies to prevent plagiarism, duplicate publication, and data fabrication. Why Publish with IJPLS? Global Visibility: As an open-access journal, IJPLS ensures that your research reaches a wide audience, increasing the impact and visibility of your work. Rigorous Peer Review: Every submitted manuscript undergoes a thorough peer review process by experts in the field to ensure the quality and reliability of the published research. Wide Coverage: We cover a broad spectrum of topics in pharmacy and life sciences, ensuring that researchers in a wide range of disciplines have a platform to share their findings. Professional Recognition: Publishing with IJPLS enhances your academic reputation and provides a professional recognition within the scientific community. Frequency and Access IJPLS is published Monthly, and all articles are freely available online upon publication. Authors and readers can access the journal’s content through the official website, ensuring global access to high-quality research. Publisher Information The International Journal of Pharmacy and Life Sciences is published by Sakun Publishing House, a leading publisher in the field of scientific research, committed to the advancement of knowledge in pharmacy, life sciences, and related disciplines.
Polyherbal Formulation for Women's Reproductive Disorders
Women's reproductive disorders such as polycystic ovary syndrome (PCOS), dysmenorrhea, endometriosis, menstrual irregularity, pelvic inflammatory disease (PID), and gonorrhea represent a significant global health burden. Conventional pharmacological treatments, though effective, are often associated with adverse effects, high costs, and long-term complications. Herbal medicine, particularly the Ayurvedic system, offers a safer and more holistic alternative. This review explores the therapeutic potential of five medicinal plants — Saraca asoca (Ashoka), Asparagus racemosus (Shatavari), Symplocos racemosa (Lodhra), Tinospora cordifolia (Guduchi), and Cinnamomum zeylanicum (Cinnamon) — in managing women's reproductive disorders. Their key phytochemicals, reported pharmacological activities, and rationale for use in a polyherbal combination are discussed. The review also highlights existing marketed Ayurvedic formulations and concludes that this combination holds strong potential as a cost-effective, evidence-based therapeutic option, warranting further clinical investigation.
Polyherbal formulation, Women's reproductive disorders, Ayurveda, Saraca asoca, Asparagus racemosus, Phytochemicals, Uterine tonic, PCOS
Amit Singh Sengar, Suman Gehlot, Satyaendra Shrivastava
Formulation and Evaluation of Digestion Enhancer Soft Gel Lozenges
Digestive disorders such as dyspepsia, bloating, flatulence and indigestion account for a huge global health burden with millions of individuals suffering from them leading to decrease in quality of life. This study reports the design and characterization of soft gel lozenges incorporating bitter leaf (Vernonia amygdalina) extract as the active pharmaceutical ingredient, integrated with fennel oil (Foeniculum vulgare) and cardamom oil (Elettaria cardamomum) as a synergistic combination. Excipients used with these active components include gulkand (rose petal preserve), rose water, gelatine. Soft gel lozenges represent a novel and patient-friendly delivery system for herbal actives, offering advantages such as ease of administration, pleasant organoleptic properties, and enhanced mucosal absorption. The formulations were characterized for physicochemical parameters including weight variation, hardness, friability, disintegration time, and in vitro drug release. The optimized formulation exhibited acceptable organoleptic properties, satisfactory stability, and effective digestive activity. These results support the potential of this herbal lozenge as a safe, effective, and palatable alternative for managing common digestive ailments.
Soft gel lozenges, herbal formulation, digestive disorders, carminative, patient compliance
Vishal Makwana, Ashutosh Nagar, Pritesh Paliwal, Nimita Manocha
Pharmaceutical Properties of the Processed Lentinus Tuber Regium Powder and its Impact on Pharmaceutical Solid Dosage Forms
Excipients are crucial in tablet formulation, influencing stability, manufacturability, and bioavailability. Synthetic superdisintegrants are widely used but limited by cost and availability in developing countries. Lentinus tuber regium (LT), a natural fungal sclerotium, offers a potential alternative, but its native form lacks optimal properties. This study explored processed LT powder as a superdisintegrant in paracetamol tablets. To evaluate the pharmaceutical properties of processed LT powder and its impact on tablet performance compared to native LT. LT was processed by boiling (BLT) or soaking in palm wine (SPLT). Physicochemical tests (density, Carr's index, Hausner's ratio, angle of repose, moisture content, swelling index) were conducted. Compatibility was assessed via FTIR, morphology via SEM. Paracetamol tablets were formulated and evaluated for weight variation, hardness, friability, disintegration, and dissolution. Statistical analysis included ANOVA and t-tests (p < 0.05). Processed LT showed superior properties: lower bulk density (0.32–0.35 g/mL vs. 0.45 g/mL for NLT), Carr's index (18.6–19.2% vs. 22.4%), and angle of repose (32–34° vs. 38.5°; ANOVA F = 15.67, p < 0.001). FTIR confirmed compatibility (r = 0.92–0.95, p < 0.001); SEM revealed uniform granules. Tablets had optimal hardness (5–6 kg), friability (<0.5%), disintegration (<2 min external, <5 min internal), and dissolution (>90% in 30 min; ANOVA F = 13.56, p < 0.001). Processed LT excels as a natural superdisintegrant, enhancing tablet performance. It offers a sustainable, cost-effective alternative for Nigeria's pharmaceutical industry, warranting further scalability studies.
Lentinus tuber regium, superdisintegrant, physicochemical properties, tablet formulation, dissolution.
Bioequivalence Assessment of Five Brands of Antimalarial Drugs Marketed in Rivers State Using Statistical Tool
Malaria remains a major public health challenge in Sub-Saharan Africa, with artemether-lumefantrine (AL) as the first-line treatment for uncomplicated Plasmodium falciparum malaria. Ensuring bioequivalence among generic AL brands is crucial for therapeutic interchangeability and effective malaria control. This study evaluated the bioequivalence of four generic antimalarial brands (Drugs A, B, C, D) against a standard AL formulation using clinical recovery time as the primary endpoint in 80 malaria patients. An Indirect Assay Design (IAD) was employed, administering five antimalarial drug brands randomly to malaria patients. The primary outcome was time to clinical recovery (in hours) following completion of treatment. Bioequivalence was assessed using ANOVA and Logistic 4-parameter equivalence tests in JMP software version 17. Equivalence was declared when 90% confidence intervals for key parameters (growth rate, inflection point, lower/upper asymptotes) fell within predefined decision limits. Parameter estimates revealed Drug A was bioequivalent to Drug C shown in parameter estimate: -4.33; SE: 2.102; tRatio: -2.06; p=0.042). Equivalence testing confirmed Drugs A and C had comparable potency profiles: growth rate ratio (2.4:0.15), inflection point (1.3:0.65), lower asymptote (1.2:0.75), and upper asymptote (1.1:0.85). Drugs B and D failed equivalence criteria, indicating potential formulation differences affecting clinical efficacy. Drugs A demonstrated statistical bioequivalence to Drug C based on recovery time analysis, ANOVA and Logistic 4-parameter equivalence tests. These findings support their therapeutic interchangeability for uncomplicated malaria treatment. Drugs B and D require further quality assessment. This study validates the use of clinical recovery time as a practical bioequivalence endpoint in resource-limited settings where pharmacokinetic studies are challenging.
Bioequivalence, Malaria treatment, Equivalence testing, Recovery time, Indirect Assay Design.
Ucheokoro, Adaeze S., Ogoke, Uchenna P. , Abali, Sunday O.
Learning Management Systems as Tools for Ensuring Academic Integrity and Quality Assurance Compliance
The accelerated digital transformation of higher education has placed Learning Management Systems (LMS) at the core of academic delivery, governance, and institutional accountability. LMS platforms have developed into essential vehicles not only to enable education and learning but also to establish systems to safeguard academic integrity as well as national and international quality assurance standards. It covers the role which LMS is playing in the promotion of transparency, prevention of academic misconduct, data integrity, accreditation, and compliance/regulatory reporting. This paper integrates modern LMS platforms with existing literature on digital integrity, including plagiarism detection, secure assessment mechanisms, proctoring technology, audit trails, analytics dashboards, and compliance monitoring. It also investigates how LMS promotes conformity for accreditation agencies and QA firms by helping with documentation, outcome mapping, assessment tracking, and the process of continuous quality improvement. Data privacy, cybersecurity, algorithmic bias, resistance from faculty, and ethical issues are discussed as difficulties to be solved. Emerging technologies, including artificial intelligence, blockchain-driven credentialing, and learning analytics, are reviewed as potential future enablers of integrity-led digital governance. This review shows how the LMS have transformed from teaching devices into institutional compliance ecosystems that can increase accountability, transparency, and enhance the quality of the higher education institutions. To achieve optimal regulatory and ethical outcomes as they arise, policy alignment, strategic implementation, and faculty training are required.
Learning Management System, Academic Integrity, Quality Assurance
Studies of Microbiological Analysis and Identification of Microorganisms in High TDS and Low TDS Waste Water of CETP Naroda
Industrial wastewater from chemical industries contains a wide range of pollutants and microorganisms which can have adverse effects on the environment and public health. This study investigates the microbial and physicochemical characteristics of wastewater collected from different treatment stages of Common Effluent Treatment Plant (CETP), Naroda, Ahmedabad. Parameters like pH, Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), Total Dissolved Solids (TDS), Total Suspended Solids (TSS), Chloride and Ammoniacal Nitrogen were analysed using standard methods. The presence of microorganisms in the raw wastewater sample despite the TDS concentration (25,000 to 15000ppm) indicates that they can decompose organic matter present in the polluted water and their identification was analysed using various agar media. Microbiological analysis was performed using culture-based techniques on selective and differential media including Nutrient Agar, McConkie Agar, EMB Agar, XLD Agar, PDA, Rose Bengal Agar, Robertson’s Cooked Meat Medium and high-TDS media. The results revealed heterotrophic bacteria such as Pseudomonas and Bacillus species, indicator organisms such as Escherichia coli, pathogenic Salmonella species, halophilic bacterial and fungal isolates mainly belonging to Mucor species. These findings shed light on the microbial diversity of wastewater entering CETP.
Waste Water, Microorganisms, Pathogenic Bacteria, Selective and Differential media.
Nancy Kothari, Patel Aditi, Parmar Zarna, Chauhan Vaibhavi1, Satish S. Patel
Microbiological Study of Solid Waste from CETP Naroda
In this study, solid waste samples were collected from the Common Effluent Treatment Plant Naroda Enviro Projects Limited (NEPL-CETP) located at Naroda. Ahmedabad GIDC and microbial studies were conducted to determine the presence of bacterial and fungal communities. This is a wastewater plant where solid waste is separated into primary and secondary by biological methods. The samples were analysed. Solid waste is managed safely and scientifically as per the norms of Gujarat Pollution Control Board.
Wastewater; Solid waste; Microorganisms; NEPL
Arpita Verma, Hemangini Mayekar, Nivedita Yadav, Bhoomika Khant, Satish S. Patel
An Imperical study of Flavonoid Fraction of Juglans regia in Diabetic rats for their Wound Healing Activity
The present work is deals with study of the wound healing activity of Flavonoid Fraction of Juglans regia Linn. (FFJR) in Diabetic Rats. From the fruits, the flavonoid fraction was prepared and flavonoid and phenolic compounds were determined. The diabetes was induced by the single administration of Streptozotocin in citrate buffer. The wound healing activity of flavonoid fraction was determined by Dead space, Incision and Excision wound models. During the experimental period the fasting blood glucose level in diabetic animals were higher than those of normal animals. However, the fasting blood glucose level was significantly reduced in treatment groups. Topical application of flavonoid fraction, ointment base and Povidone iodine on dorsal inter scapular region causes significant and faster rate of wound closure and reduced epithelialization period. In incision wound model, there is a significant increase in skin tensile strength by 10% w/w and 20% w/w ointment of FFJR compared to control. The hydroxyproline content was increased significantly in dose dependent manner by 20% FFJR. FFJR significantly decreased the epithelialization period, hence have significant effect on the proliferative phase of wound healing in diabetic rats.
Mahavir Chhajed, Reena Jain Lodha, Atika Jain Chhajed, Abhimanyu Singh Rathore, Amit Bukkawar, Sandeep Wathore, Pallavi Patil,Pooja Sinha
Laboratory Information Management Systems (LIMS) and Laboratory Automation: Enhancing Data Integrity and Regulatory Compliance
Laboratory Information Management Systems (LIMS) and laboratory automation are the foundational technologies in contemporary analytical, clinical, and pharmaceutical laboratories. These digital platforms create the smoothest workflow, optimize data management, comply with regulations, and reduce both human error and operational disruptions. The current publication is a review of the evolution, main functions, and advantages of LIMS and Laboratory Automation focused on the ways in which they strengthen data integrity, traceability, and meeting regulatory requirements, including GLP, GMP, ISO, and FDA 21 CFR Part 11. It also emphasizes the integration with advanced technologies such as artificial intelligence (AI), Internet of Things (IoT), cloud computing, and the challenges and forward-looking orientation for the transformations of the digital lab ecosystem. As a paper, this article reflects the need for laboratories to embrace integrated LIMS and automation frameworks in the digital transformation to stay competitive, compliant, and efficient in the era of digital transformation
LIMS, Laboratory Automation, Data Integrity
An Integrative Review of Herbal and Complementary Therapies in the Management of Vaginal Infections
Vaginal infections represent one of the most prevalent gynecological conditions affecting women across all age groups, with vulvovaginal candidiasis being the most frequently reported fungal etiology. Candida albicans, a commensal organism of the vaginal microbiota, may become pathogenic under conditions such as immune suppression, hormonal imbalance, antibiotic overuse, and lifestyle factors, leading to recurrent and persistent infections. Although conventional antifungal and antibacterial therapies remain the cornerstone of treatment, their repeated use is often associated with adverse effects, resistance development, and high recurrence rates. Consequently, interest has grown in herbal and complementary therapeutic approaches that offer multi-targeted, safer, and culturally accepted alternatives. Traditional systems of medicine, including Ayurveda, Unani, and ethnomedicine, describe numerous botanicals with antifungal, anti-inflammatory, immunomodulatory, and probiotic-supporting properties. This review critically examines the etiology and classification of vaginal infections, limitations of conventional therapy, ethnopharmacological evidence, experimental and clinical studies on herbal interventions, and lifestyle-based supportive measures for vaginal health. Emphasis is placed on herbal formulations, single-plant remedies, and integrative strategies that promote vaginal comfort, microbial balance, and long-term wellness.
Vaginal infection, Vaginitis, Candida albicans, Herbal medicine, Ethnopharmacology
Microbial Resistance: A Comprehensive Review on the Emerging Role of Bionanomaterials
Microbial resistance to conventional antimicrobial agents has emerged as one of the most critical global health challenges of the 21st century. The rapid evolution of resistant bacterial, fungal, viral, and parasitic strains has significantly reduced the effectiveness of existing antibiotics, leading to increased morbidity, mortality, and healthcare costs worldwide. Factors such as the overuse and misuse of antibiotics, poor infection control practices, and limited development of new antimicrobial agents have accelerated this crisis. In this context, bionanomaterials have gained considerable attention as innovative and promising alternatives to traditional antimicrobial therapies. Bionanomaterials, derived from biological sources or synthesized using green chemistry approaches, exhibit unique physicochemical properties such as nanoscale size, large surface area, enhanced bioavailability, and multifunctional mechanisms of action. These materials can effectively combat microbial resistance through mechanisms including membrane disruption, reactive oxygen species generation, inhibition of biofilm formation, and targeted drug delivery. This review provides a comprehensive overview of microbial resistance, its underlying mechanisms, and the limitations of current antimicrobial strategies. Furthermore, it critically discusses the role of bionanomaterials—including metallic nanoparticles, polymeric nanoparticles, lipid-based nanocarriers, and phytochemical-loaded nanostructures—in overcoming antimicrobial resistance. Recent advances, challenges, safety concerns, and future perspectives of bionanomaterial-based antimicrobial strategies are also highlighted. The review emphasizes the potential of bionanomaterials as next-generation therapeutics to address the growing threat of microbial resistance.
Microbial resistance, antimicrobial resistance, bionanomaterials, nanoparticles,
AI-Driven Discovery of Novel Polymers: A Comprehensive Review
The discovery and optimization of polymeric materials have traditionally relied on experiment-driven, trial-and-error workflows that are time-consuming and resource intensive. Artificial intelligence (AI) — particularly machine learning (ML), graph neural networks (GNNs), generative models, and active learning — is transforming polymer science by enabling rapid property prediction, inverse design, and closed-loop experimental optimization. This review surveys recent advances (2018–2025) in data resources, polymer representations, predictive and generative AI models, optimization strategies (including Bayesian optimization and active learning), and automated/self-driving laboratories. We highlight landmark platforms (Polymer Genome, Open Macromolecular Genome), methodological progress (multitask GNNs, chemical language models such as polyBERT, and benchmarks for deep generative models), and successful demonstrations of AI-assisted polymer discovery in energy, electronics, healthcare, and sustainable plastics. Key challenges remain: scarcity and heterogeneity of polymer data, difficulty representing polymer ensembles and architectures, synthetic feasibility of generated candidates, model interpretability, and integration with experimental workflows. We discuss strategies to address these issues — standardized databases and representations, self-supervised learning, synthesis-aware generative models, and tighter AI–robotics integration — and outline opportunities where AI can accelerate green polymer chemistry, circular-economy polymers, and application-directed multi-property optimization. The review concludes by advocating for community efforts in data curation, open benchmarks, and interdisciplinary training to realize AI’s promise for fast, cost-effective polymer innovation.
Exploring the Therapeutic Potential of Naringin: Chemical Attributes and Pharmacological Evidence
Naringin is a naturally occurring flavanone glycoside predominantly found in citrus fruits, especially Citrus paradisi (grapefruit), and has gained considerable scientific interest due to its broad spectrum of pharmacological activities. Chemically, naringin consists of a flavanone nucleus conjugated with disaccharide moieties, conferring antioxidant and biological activity. Upon metabolism, naringin is converted into its aglycone naringenin, which plays a crucial role in mediating its therapeutic effects. Extensive preclinical studies have demonstrated that naringin exhibits antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, hepatoprotective, neuroprotective, and antidiabetic activities through modulation of oxidative stress, inflammatory mediators, apoptosis pathways, and cellular signaling cascades. However, its poor aqueous solubility and limited oral bioavailability pose significant challenges for clinical translation. Recent advances in formulation strategies, particularly nano-based delivery systems, have shown promise in overcoming these limitations. This review provides a comprehensive overview of the chemical properties, metabolism, and diverse pharmacological activities of naringin, along with current challenges and future perspectives for its therapeutic application.
Naringin, Flavonoid, Citrus bioactives, Pharmacological activities, Antioxidant
Therapeutic Potential of Berberine in Hypertension: A Narrative Review
Hypertension is one of the most prevalent chronic diseases worldwide and a leading contributor to cardiovascular morbidity and mortality. Despite the availability of effective antihypertensive drugs, blood pressure control remains suboptimal in many patients, prompting growing interest in complementary and plant-derived therapies. Berberine, a natural isoquinoline alkaloid isolated from plants such as Coptis chinensis and Berberis species, has been used in traditional medicine for centuries and is now receiving increased scientific attention for its cardiovascular benefits. Experimental and clinical studies suggest that berberine may reduce blood pressure through multiple mechanisms, including improvement of endothelial function, activation of AMP-activated protein kinase (AMPK), modulation of the renin–angiotensin–aldosterone system (RAAS), and anti-inflammatory and antioxidant effects. This review summarizes and explains the current evidence on berberine and hypertension, with in-text citations and references presented according to APA style.
Berberine, Hypertension, Blood pressure, Endothelial dysfunction, AMPK, Complementary medicine
Development and Evaluation of Mucoadhesive Gastroretentive Floating Microspheres Containing Hydroalcoholic Extract of Passiflora foetida Leaves
This study focuses on the development and evaluation of mucoadhesive gastroretentive floating microspheres encapsulating the hydroalcoholic extract of Passiflora foetida leaves, aiming to enhance its therapeutic efficacy and bioavailability for the treatment of gastric ailments. Passiflora foetida, a medicinal plant known for its antiulcer, antioxidant, anti-inflammatory, and analgesic properties, was extracted using a hydroalcoholic solvent system to preserve its bioactive constituents. The floating microspheres were prepared using the solvent evaporation technique with mucoadhesive polymers such as hydroxypropyl methylcellulose (HPMC), sodium alginate, and chitosan to ensure prolonged gastric retention and controlled drug release. Characterization of the microspheres revealed spherical morphology with optimal particle size suitable for gastric retention. The formulation demonstrated high encapsulation efficiency and excellent buoyancy in simulated gastric fluid, remaining afloat for over 12 hours. In vitro release studies showed a sustained release profile, indicating controlled drug delivery potential. Further in vivo and clinical investigations are recommended to validate these findings and facilitate potential pharmaceutical applications.
Passiflora foetida, mucoadhesive microspheres, gastroretentive, floating system, hydroalcoholic extract, controlled release
Sumeet Dwivedi, Rajesh Kumar Chawla, Naresh Ambekar
Plants used by tribes of Rewa (Madhya Pradesh) in the treatment of liver disorders
Ethnomedicinal knowledge held by tribal communities in Rewa district (Vindhya region), Madhya Pradesh, includes a variety of plant remedies for liver-related ailments such as jaundice, hepatitis-like symptoms, abdominal pain associated with hepatic dysfunction, and other “liver troubles.” This review synthesizes published ethnobotanical surveys from Rewa and adjacent tribal areas to summarize commonly used species, modes of preparation, plant parts used, and the evidence base supporting their traditional hepatoprotective use. The review highlights 10 frequently cited taxa (including Ocimum canum, Phyllanthus spp., Boerhavia diffusa and others), summarizes preparation methods (decoctions, pastes, seeds/seed extracts), discusses methodological strengths and limitations of the primary surveys, and identifies priorities for pharmacological validation and conservation. Documentation and scientific validation of tribal remedies from Rewa may inform future hepatoprotective drug discovery and local healthcare support.
ethnomedicine; Rewa; liver disorders; jaundice; hepatoprotective; tribal medicinal plants
Novel Nanogel Formulation, Evaluation, and Applications: A Review
Nanogels — nanoscale, highly hydrated polymeric networks — combine the advantages of hydrogels (high water content, biocompatibility) and nanoparticles (tunable size, surface functionality) to form versatile carriers for drugs, biomacromolecules, genes and vaccines. Recent years have seen rapid innovation in materials, cross-linking chemistries, stimuli-responsive designs, and application-specific formulations (e.g., ocular, topical, wound, CNS, cancer). This review summarizes contemporary formulation approaches, critical physicochemical and biological evaluation methods, representative biomedical applications, and practical translational challenges (stability, scalability, regulatory hurdles). Emphasis is placed on “novel” aspects: green and bio-inspired chemistries, multifunctional stimuli-responsive nanogels, combination/theranostic systems, and strategies improving in vivo stability and targeting. Key gaps and future directions for clinical translation are highlighted.
Innovations in QSAR for Accelerated Development of Selective Anti-Breast Cancer Molecules
Quantitative structure–activity relationship (QSAR) modeling remains a cornerstone of ligand-based drug design. Recent methodological innovations — including deep learning, graph neural networks, multi-task models, transfer learning, and integration with structure-based methods — have increased QSAR’s power to predict and prioritize anti-breast cancer compounds. This review synthesizes modern QSAR developments relevant to breast cancer drug discovery, examines datasets and validation best practices, highlights representative case studies where QSAR accelerated identification of selective inhibitors, and discusses persisting challenges and future directions. Key themes include descriptor design and representation learning, multi-target and context-aware models for tumor subtypes, interpretability and model uncertainty, and practical integration with ADMET prediction and experimental pipelines. (Keywords: QSAR, deep learning, breast cancer, 3D-QSAR, GNN, ADMET, ChEMBL).
Integrative Ethnopharmacology of Indian Medicinal Plants for Sickle Cell Disease Management: Bridging Tradition with Evidence-Based Medicine
Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by polymerization of deoxygenated hemoglobin S (HbS), red blood cell (RBC) sickling, hemolysis, vaso-occlusion, and multi-organ complications. Conventional pharmacotherapy (e.g., hydroxyurea, L-glutamine, voxelotor) improves outcomes but remains costly, partially effective, and not universally available; moreover, many patients in low-resource settings rely on traditional medicine. Phytotherapeutic approaches — empirical herbal remedies and plant-derived bioactive compounds — have been studied for antisickling, antioxidant, membrane-stabilizing, and anti-inflammatory activities. India, with its rich ethnobotanical traditions, presents many candidate plants for SCD management. This review synthesizes current knowledge on Indian medicinal plants with reported anti-sickling or supportive activities, summarizes common experimental models and mechanisms, evaluates the quality of evidence, and outlines research priorities for translating ethnobotanical leads into safe, standardized, and evidence-based phytotherapeutics.
Sickle Cell Anemia, Medicinal Plants, Phytotherapy
Neuropharmacological Studies on Anxiety-Reducing Effects of Sarcostemma acidum Aerial Parts
The present investigation was undertaken to comprehensively evaluate the anxiolytic potential of the aqueous extract prepared from the aerial parts of Sarcostemma acidum (Roxb.) Voigt, a traditionally utilized medicinal plant. In this study, Swiss albino adult mice were employed as experimental models to assess behavioral changes associated with anxiety-like conditions. The anxiolytic activity of the extract was determined primarily using the Light–Dark Box test, a widely accepted behavioral paradigm that measures the innate aversion of rodents to brightly illuminated areas. Additionally, motor coordination and possible neuromuscular impairment were evaluated through the Rota Rod test, ensuring that any observed anxiolytic response was not accompanied by sedative or muscle relaxant effects. The aqueous extract was administered orally at dose levels of 200 mg/kg and 400 mg/kg body weight and its efficacy was compared against the standard benzodiazepine anxiolytic drug, diazepam (1 mg/kg, i.p.). Behavioral observations revealed that treatment with the extract resulted in a significant and dose-dependent increase in the duration spent in the brightly illuminated compartment of the Light–Dark Box, along with an increased frequency of transitions between the two chambers. These effects suggest a reduction in anxiety-driven responses and improvements in exploratory behavior. The extract did not induce noticeable deficits in motor coordination, indicating that its anxiolytic action is likely independent of sedative effects. Collectively, the findings demonstrate that the aqueous aerial extract of Sarcostemma acidum exhibits promising anxiolytic properties and highlights its potential as a natural therapeutic agent for managing anxiety-related disorders.
Sarcostemma acidum, Diazepam, Anxiolytic Activity
1st INTERNATIONAL CONFERENCE ON ROLE OF DIGITAL TECHNOLOGIES IN INNOVATION, ENTREPRENEURSHIP AND STARTUP (ICRDTIES) (HYBRID MODE)
AI- Powered Prescription processing: From Entry to Dispensing
Artificial Intelligence (AI) is revolutionizing multiple industries, including healthcare and pharmacy. Its integration across prescription processing and clinical decision-making enhances accuracy, safety, and efficiency. This review explores the role and benefits of AI in pharmacy practice, with a focus on prescription processing, dispensing, ADR prediction, and EHR integration. A comprehensive literature review was conducted on the applications, benefits, and challenges of AI in pharmacy using peer-reviewed journals and clinical case examples. AI has demonstrated significant contributions in ADR detection, clinical decision support systems, CPOE, drug-drug interaction prediction, and dispensing automation. Improved patient safety, efficiency, and regulatory compliance are major outcomes. Incorporating AI into pharmacy practice provides a transformative opportunity for better patient care. Pharmacy education and policies must adapt to facilitate its ethical and effective implementation. AI has made great strides in the healthcare industry, playing important roles in the management and storage of data and information, including patient medical histories, medication inventories, sale records, and so forth; automated equipment; software and computer applications, including diagnostic tools like CT and MRI radiation technology, and many more, have all been developed to support and streamline healthcare procedures. Healthcare has undoubtedly been transformed by AI to become more effective and efficient, and the pharmacy industry is not an exception. Drug development, dosage form design, polypharmacology, and hospital pharmacy are just a few of the significant pharmacy domains that have seen a significant increase in interest in the application of AI technology in recent years. Because AI is becoming more and more important, we decided to write a thorough report that would help all practicing pharmacists grasp the major advancements made possible by the use of this subject.
Artificial intelligence, pharmacy, pharmacist, polypharmacology, technology
Evaluation of Anti-ulcer Activity in Various Extracts of Crateva religiosa using Acetic acid induced Ulcer Model
Crateva religiosa is the most widely cultivated species in Northwestern India, is the sole genus in the family Capparacea.. It comprises 10 species from tropical and subtropical climates, ranging in size from tiny herbs to massive trees. The most widely cultivated species is Crateva religiosa (CR ) The most used parts of the plant are rich in polyphenols, phenolic acids, flavonoids, alkaloids, tannins and saponins. The high number of bioactive compounds might explain the pharmacological properties. Many studies, in-vitro and in-vivo, have confirmed these pharmacological properties. The present investigation was carried out to evaluate anti-ulcer activity of various extract of the plant parts using acetic acid induced ulcer models.
Crateva religiosa (CR) Anti-ulcer activity, acetic acid induced ulcer
In Silico Molecular Docking of Bioactive Molecules: An Overview
Computational approaches have become indispensable in modern drug discovery and development. Among them, in silico molecular docking serves as a vital tool for predicting the binding affinity, orientation, and interactions of bioactive molecules within the active site of biological targets. Docking helps understand structure–activity relationships (SARs), guides lead optimization, and reduces experimental costs by prioritizing promising compounds before synthesis and biological evaluation. This review provides an overview of molecular docking theory, types of docking algorithms, commonly used software, validation parameters, and examples of applications in studying bioactive natural products and synthetic molecules. The integration of docking with molecular dynamics (MD) simulations, quantitative structure–activity relationship (QSAR) modeling, and in vitro assays is also discussed. Challenges such as receptor flexibility, scoring inaccuracies, and water-mediated interactions are considered, along with emerging advances in artificial intelligence (AI) and deep learning-based docking algorithms. Overall, in silico molecular docking remains a cornerstone computational method for rational drug design and bioactivity prediction of natural and synthetic molecules.
molecular docking, bioactive molecules, computational chemistry, structure–activity relationship, drug discovery, in silico modeling
Digital Therapeutics: regulatory Challenges for AI-based Healthcare Solutions
Modern healthcare is changing as a result of the incorporation of Artificial Intelligence (AI) into digital treatments, which provide evidence-based, scalable and customized software based interventions. These AI-powered technologies have enormous promise for improving patient adherence, controlling chronic illnesses, and providing immediate clinical assistance. But because they are developing faster than current regulatory frameworks, there is a serious supervision, validation, and accountability vacuum. This review examines the intricate regulatory concerns surrounding AI-based digital therapies, such as those pertaining to data protection, real-world proof requirements, algorithm transparency, and software categorization. It also looks at how inconsistent regulatory requirements are throughout the world and how hard it is to stay up with AI systems that are flexible and always learning from fresh data. This article emphasizes the essential need for a unified and flexible regulatory environment that strikes a balance between innovation, patient safety and ethical responsibility through a multidisciplinary perspective. The information offered is intended to help developers, regulators and healthcare stakeholders create governance frameworks that can facilitate the safe and efficient application of AI in therapeutic contexts.
Artificial Intelligence (AI), digital, regulatory, real-world, therapeutic.
Gourav Gupta, Akanksha Dwivedi*, G.N. Darwhekar
Pharmacological Treatment and Emerging Therapies on Hyperlipidemia
Angiopoietin-like protein 3 (ANGPTL3) and apolipoprotein C-III (Apo C-III) and their functions in cardiovascular health and lipid metabolism. The liver's production of Apo C-III prevents triglyceride-rich lipoproteins from breaking down, which raises triglyceride levels and raises the risk of cardiovascular disease. Those who have mutations that cause the APOC3 gene to malfunction have much lower triglyceride levels and a lower chance of developing ischemic heart disease. In an effort to mimic the protective effects observed in APOC3 deficiency, treatments that target Apo C-III, such as plozasiran, olezarsen, and volanesorsen, have been developed. As a therapeutic target, ANGPTL3 has also been identified, and evinacumab, a monoclonal antibody, is currently being used in clinical settings. To completely comprehend the effectiveness and safety of these novel treatments, further extensive long-term research is necessary.
Liver, Cardiovascular disease, Hyperlipidemia
Ishika Panchal*, Gaurav Goyanar, Nirmal Dongre
Indigeneous ayurvedic knowledge of some species in the treatment of human disease and disorders
Medicinal plants have always been the principle sources of medicine in India. Since ancient past and presently they are becoming popular. Various system of medicine including Ayurveda reveals the uses of several herbs in the treatment of human ailments. There has been a rapid extension of allopathic system of medical treatment in our country during the past century and due to severe and high adverse effects the knowledge of traditional medicine came into light with ancient experiences. The present paper emphasis the indigeneous ayurvedic knowledge of 80 species belonging to different families used in the treatment of various human disease and disorders.
Arthritis an autoimmune disorder: Demonstration of In-vivo anti-arthritic activity
In the normal knee joint, the synovium consists of a synovial membrane (usually one or two cells thick) and underlying loose connective tissue. Synovial-lining cells are designated type a (macrophage-like synoviocytes) or type B (fibroblast-like synoviocytes). Arthritis is an auto immune disorder characterized by pain, swelling and stiffness. Its prevalence depends upon age. It occurs more frequently in women than in men. It is an inflammation of synovial joint due to immuno mediated response. All anti inflammatory drugs are not anti arthritic because it does not suppress T-cell and B-cell mediated response. For evaluation of anti arthritic drugs inflammation and T-cell and B-cell mediated response by including foreign antigen should be suppressed. The high incidences of anti-CII antibodies and CII-specific T cells indicate that CII is one of the major auto antigens of human RA. In this way, the higher prevalences of CII-specific antibodies and T cells noted during the early phase of RA indicate that CII-specific immunity plays an important role in the initiation of inflammation in the articular joints. So, collagen type-II is best model for evaluation of anti-arthritic drugs compare to other models.
Arthritis, synovial joint, synoviocytes, auto antigens
Anthelmintic activity of polyherbal preparation
The present study was done with the aim to investigate the anthelmintic activity of different herbs in polyherbal combination. The aqueous and ethanolic extract of the different concentration were tested which involve determination of paralysis time and time to kill the worms. Piperazine citrate was used as standard and it was found that the PHF ethanolic extract activity is higher than PHF aqueous extract.
Anthelmintic activity, piperazine citrate, herbs
Effects of Asparagus racemosus, (shatavari) on mounting behaviour of male rats
Shatavari, (Asparagus racemosus), belonging to family Liliaceae is a climbing plant which grows in low jungles areas throughout India. It is useful for infertility, decreased libido, threatened miscarriage, menopause and leucorrhea and has the ability to balance pH in the cervical area. The present paper deals with the mounting behavior of satavari in male fats and found profound results.
Shatavari, mounting behaviour, aphrodiasiac agents
Mishra Vinay Kumar*, Sheikh Saima, Agnihotri Vineet and Chourey Nitin