Formulation and Evaluation of Mouth Dissolving Tablets of Ondansetron Hydrochloride

Abstract

The present work was designed to formulate and evaluate Mouth dissolving tablets of ondansetron hydrochloride by direct compression technique. Mouth dissolving tablets were prepared by direct compression method using superdisintegrants like crospovidone (CP), croscarmellose sodium (CCS), sodium starch glycollate (SSG) and combination of super-disintegrates in different concentrations. The prepared formulations were evaluated for the pre-compression parameters like bulk density, tapped density, Carr’s compressibility, Hausner’s ratio and angle of repose. The prepared batches of Mouth dissolving tablets of ondansetron hydrochloride were evaluated for hardness, weight variation, thickness, friability, drug content, disintegration time, wetting time, water absorption ratio, and in vitro dissolution profile. The ondansetron hydrochloride formulation were within the acceptance limit .and release rate of all prepared ondansetron hydrochloride were distinctly higher as compared to pure drug. All the Preformulation parameter were evaluate such as organoleptic characterization of the drug sample, melting point , pH, identification of drug sample by using UV spectroscopy and FTIR analytical methods. Preparation of Calibration curve , solubility studies of drug sample like quanlitive, quantitative and pH-depended solubility of the drug in a buffer solution. All Pre-compression parameter like Bulk density and Tapped density, Angle of repose were found in the range of 0.412–0.433 g/cc and 0.508–0.534 g/cc ,26.470 to 29.450 respectively. In all formulations & Evaluation post compression parameter like, Tablet weight variation and thickness were within mean±7.5% and mean±5% respectively. Wetting time values lie between 19.50 to 35.70 sec. Water absorption ratio ranged from 76.66 to 91.66 %. The in vitro disintegration time for all the 10 formulations varied from 21.24 to 41.22 seconds. Formulation F10 which contained crosspovidone have recorded drug release 99.98±0.06% at the end of 30 min. The formulation containing Sodium Starch glycollate, Crosscarmellose cellulose & crospovidone (F10) showed better performance in terms of disintegration time and drug release when compared to other formulations.