Development and In-vitro Evaluation of film coated tablet of Norfloxacin and Tinidazole

Abstract

In the present work, film coating technique successfully used for the taste masking of bitter tested drugs. Also the 2% film coating shows no any effect on the physical as well as performance parameters of the tablets. The formulation variable, i.e. different binders in different concentration used influence in vitro drug release profile, disintegration time and micromeritic properties of the prepared tablets. The excellent disintegration time offers the better immediate release profile of the tablets. The film coated technology employed, gives immediate release profile along with taste masking and smooth elegance. This results in burst release of drugs and successively rapid absorption through stomach to attain therapeutic plasma concentration. Stability studies show that drug content was within a range as per IP specifications. Also there was no change in colour seen during stability studies. Also the present work relates with two simple, accurate and reproducible spectrophotometric methods have been developed for the simultaneous estimation of Norfloxacin and Tinidazole which can be employed for the routine estimation of NF and TZ in both bulk and tablet dosage form.