Formulation and Evaluation of Colon Targeted Drug Delivery

Abstract

The primary aim of this study is to create a targeted drug delivery system for Mesalamine, specifically aimed at the colon. Nine different formulations of Mesalamine tablets were developed using a combination of microbial degradation polymers such as Inulin, Locust bean gum, and Xanthan gum, along with MCC, PVPK30, magnesium stearate, and talc through the direct compression method. Various parameters including hardness, weight variation, drug content uniformity, friability, and in vitro drug release were evaluated for all the prepared tablets. FTIR studies indicated the absence of interactions between the drug and polymers. Among the formulations, F9 demonstrated the highest in vitro drug release of 96.25% over 12 hours, thus establishing it as the optimized formulation.