Application of inevitable botulinum toxin in migraine: A Review

Abstract

Botulinum Toxin is acclaimed to be the most catastrophic of all the poisons, today this toxin has emerged as a boon in the field of medical sciences because of its multiple uses and has fabulously enhanced the practices of nation’s dermatologist, neurologists and pain specialists. This toxin has a tremendous track record of more than ten years of spectacular efficacy and remarkable safety profile with least side effects. In   April 2002, US FDA has approved this toxin for cosmetic use and in 2004 it also got the approval for Hyperhidrosis. From past fifteen years various controlled trials have been done and they revealed the use of botulinum toxin in Chronic Migraine and as well as chronic tension type headaches. Herein we review the history, biochemical aspects, mechanism of action and clinical evidences which prove its use in migraine.