Synthesis, characterization and anti bacterial activity of some novel tryptamines bearing pyrrolidin-2-one moiety

Abstract

A series of Novel pyrrolo tryptamines were synthesized,characterized and screened for their anti-bacterial activities. The structures of the synthesized compounds were established by 1H-NMR AND ¹³ C-NMR spectroscopic analyses. The anti-bacterial activities of compounds were studied by disc diffusion method. All compounds were tested against three Gram positive and three Gram-negative bacteria. All compounds revealed better results against Gram positive as compared to Gram-negative bacteria. But 4-Amino-5-(5-hydroxy-1H-indol-3-yl)-pyrrolidin-2-one was found most potent compound showing broad spectrum activity when compared with other compounds.