Longitudinal clinical evaluation of antibiotic use among patients with infecton

Abstract

The present study aimed to evaluate clinical outcomes of used antibiotic among patients with infection and to compare sociodemographics with the type of infection and used antibiotic. A 6-week prospective longitudinal analysis was performed among patient who receive antibiotic in general ward HUSM. Patients were selected on the basis of used antibiotic and diagnosis of infection. Patient follow-ups were made on daily basis until discharge from hospital. All laboratory data were recorded to determine clinical outcome. Statistical analysis was undertaken using SPSS 17^®. The total of sample was 44 patients (100%). Among them, 23 patients were males (52.3%) and 21 patients were females (47.7%). Majority 42 (95.45%) were derived from the Malay race and 2(4.55%) were Chinese. A 6 (13.64%) patients were identified as smoker. The age of patients in treatment was mean±SD (57.18±17.84) years and length of stay was mean±SD (7±4.57) days of treatment. Empirical theraphy was considered among 86.36% patient as it was not verified infection by culture and sensitivity test and only 6 (13.63%) as definitive therapy, 4 (66.67%) of them with mixture of gram (+) cocci and MRSA. Clinical outcomes showed 30 patients (68.18%) discharged without complication, 13 patients (29.55%) discharged with complication, and 1 patient (2.27%) transferred to other ward. There is no significant association between antibiotic with sociodemographics (p>0.05). No significant variance in betwen antibiotics with diagnosis type of infection and clinical outcomes (p>0.05) while in contrast there is a significant relationship between antibiotics with comorbidity (p< 0.05).  Majority of antibiotics treatment were given based on empirical therapy not definitive therapy. There were no association among antibiotic use with sociodemographics and clinical outcomes.