Development and Validation of RP-HPLC method for Simultaneous estimation of combined drug in Pharmaceutical formulation

Abstract

Analytical techniques hold the key to the design, development, standardization and quality control of medical products. In the present research work a modest attempt has been made to develop validated analytical methods for the determination of single or combined dosage form. Research had done to developed simple, rapid and sensitive, stable and highly effective simple RP-HPLC method for determination of Nebivolol HCL and Telmisartan, to validate methods as per ICH Guidelines, to analysed Nebivolol HCL and Telmisartan using validated methods quantitatively and qualitatively. Solubility,wavelength, Optimization of chromatographic condition, Linearity, System Suitability test, proposed method for estimation of both drugs,validation studies performed in this article. Method successfully quantified the selected analytes from tablet formulation.No interference of additives etc.is encountered in this method further studies on other pharmaceuticals formulation would throw more light on those study.