Hypolipidemic activity of Ailanthus excelsa Roxb.

Abstract

Methanolic extract of Ailanthus excelsa leaves and its fractions were investigated for hypolipidemic activity on triton induced hyperlipidemic model. Methanolic extract decreased total Cholesterol level upto 02.22, 04.36, 05.57 and 11.01% in 50, 100, 200 and 300mg/kg body weight dose respectively. On the other hand methanolic extract increased HDL level upto 0.74, 01.33, 02.37 and 03.02% in 50, 100, 200 and 300mg/kg body weight dose respectively. methanolic extract decreased Triglycerides level upto 09.87, 10.72, 12.34 and 13.04% in 50, 100, 200 and 300mg/kg body weight dose respectively. methanolic extract decreased LDL-cholesterol level upto 04.50, 06.46, 06.79 and 09.04% in 50, 100, 200 and 300mg/kg body weight dose respectively. methanolic extract decreased VLDL-cholesterol level upto 09.87, 10.73, 12.35 and 13.05% in 50, 100, 200 and 300mg/kg body weight dose respectively. Initial total cholesterol of isolate CT1 treated group was found to be 134.83±1.99 which was increased upto 161.16±7.02 by triton. After the treatment with isolate CT1 the total cholesterol level was decreased upto 134.16±1.52. In this group the initial HDL was 22.58±1.07 which was increased upto 24.83±2.21 by triton and after the treatment with isolate CT1 it was reached normal level upto 22.33±0.91. The initial level of triglyceride was 76.00±1.29 which was increased upto 90.25±3.62 by triton and after the treatment with isolate CT1 it was decreased upto 78.75±1.58 and the initial LDL-cholesterol level was 97.05±1.97 which was increased upto 119.28±4.45 and after treatment with isolate CT1 it was reduced upto 94.48±2.33.