In Vitro Anthelmintic activity of some Novel N-substituted Imidazolin-5-one derivatives

Abstract

A series of N-substituted imidazolin-5-ones were synthesized by oxazole condensation followed by amination with various heterocyclic amines in presence of ethanol and few drops of glacial acetic acid. Structures of the compounds were characterized on the basis of IR, C¹³NMR and H¹NMR. Compounds 1a-7a and 1b-7b were screened for antihelmintic activity .Test results revealed that compound 5a and 5b  showed paralysis time  of 2.5 and 2.75 min and death time of 9 and 8.5 min while the standard drugs albendazole showed paralysis time of 11 min and death time of 21min, respectively, at the same concentration of 50mg/ml. All compounds were found to posses both vermifuge and vermicide properties.