Determination of maximum tolerated dose of combination of Lamotrigine and 5-fluorouracil by oral route in swiss albino mice for further In Vivo Anticancer activity

Abstract

The cancer disease has created a great demand for the discovery and development of new drug molecules. The major problem with the cancer chemotherapeutics is the toxicity by the current existing anti cancer drugs and anti tumor drug resistance by the cancerous cells to the anticancer agents. These two major problems can be overcome by the discovery and usage of new novel cancer chemotherapeutic agents and going with the new drug combinational therapeutics. 5-Fluorouracil is an antimetabolite whose usage has reduced due to severe toxicity and drug resistance when used individually. Lamotrigine is an anti epileptic drug which has diversified mechanisms of action, and which is believed to be act as an ideal anticancer agent. In the present study the safe and maximum tolerable dose of the combination of both Lamotrigine and 5-Fluorouracil are determined for further in vivo anticancer activity studies in swiss albino mices.