Formulation and Evaluation of Disulfiram Medicated Chewing Gum

Abstract

Chewing gums are mobile drug delivery systems. Unlike chewable
tablets, medicated gums must not be swallowed and can be removed
from the application site without resorting to invasive means. Medicinal
chewing gums are a solid single-dose preparation. They contain one or
more active ingredients, which are released by chewing and are intended
to be used for the local treatment of oral diseases or systemic intake after
absorption by the oral mucosa. As for patient comfort, its discreet and
easy administration without water promotes greater compliance. Since it
can be taken anywhere, the chewing gum formulation is an excellent
choice for acute medications. In the present study, chewing gum
medicated with Disulfiram was formulated with beeswax as base,
glycerol, castor oil, dextrose, calcium carbonate, polyvinylpyrrolidine,
aerosol, magnesium stearate and peppermint oil.
This medicated chewing gum was prepared with a direct compression method and formulated using
various compositions of plasticizer castor oil and dextrose.
The medicated chewing gums developed by Disulfiram were smooth, light yellow in color with a mint
flavor. The presence of glycerine at an optimized concentration provided the softness for the medicated
chewing gum developed. The average content of the drug in the developed medicated chewing gum was
94.14%, confirming the success of the formulation and the methodology used for its development. The
drug release profile for medicated chewing gums can be significantly influenced by the frequency of
chewing, therefore the drug release rate from the developed MCG was measured the maximum drug
release of 94.37% was reported after 30 minutes of study on the dissolution of Batch F4.