Molecular Approaches in Anticancer Drug Development: A focused on Targeted Therapies

Abstract

This paper highlights the need for study into the development of effective customized targeted therapies with the potential to overcome pharmaceutical resistance while also decreasing toxicity and unwanted effects.  Extensive structural studies, genetic and biochemical research, and the discovery of new druggable targets are essential components of the drug development framework necessary to achieve this aim.    To further molecular focused therapy, new medications with different chemical entities or action mechanisms are required.  Additional methods for cancer-specific control beyond director allosteric modulation include posttranslational modification and targeted protein degradation utilizing proteolysis-targeting chimera (PROTAC).