Design and Characterization of Nanosponges Drug Delivery System for Water soluble and insoluble actives

Abstract

Nanotechnology revolutionized drug delivery systems by maximizing the solubility, stability, and bioavailability of drug molecules. Of all the various nanocarriers, nano sponges have emerged as a very efficient drug delivery system due to the sponge-like porous structure that favors effective encapsulation and controlled delivery of water-soluble as well as water-insoluble actives. This study aims at the synthesis, design, and characterization of β-cyclodextrin-based nano sponges for the targeted and sustained delivery of Acelofenac (ACE), an insoluble water nonsteroidal anti-inflammatory drug (NSAID). The study aims to optimize the nano sponge formulation for better drug solubility, release duration, and therapeutic response.