Synthesis, Characterization and Antimicrobial activity ofAzetidine derivatives

Abstract

In present study azetidine derivatives were synthesized and microbial activity of different derivatives were checked with various microbial stain. Various intermediates was synthesized and characterized in between time to time by chromatography and special methods. Substituted salicylic acid and sulphuric acid were starting material and finally formed2-Hydroxy –N-)2-oxa-4-phenylazet-1(2H)0yl)benzamide(D), while in the intermediate steps(A) Ethylsalicylate react with hydrazine hydrate to get,(B) Salicyl Hydrazide, and this (B) compound reflux with sulphuric acid to get (C) 2 -hydroxy-N-[(Z)- phenylmethylidene]benzohydrazide. Azetidine derivatives have been synthesized from Schiff base of the corresponding hydrazine by using ethanol with reflex. The structure of the entire synthesized compound was established on the basis of element, chromatography and spectral analysis. The synthesized compound was evaluated for their antimicrobial activity. The compound most active be against Staphylococcus aureus ,Bacillus subtillis