Anxiolytic Activity of hydroalcoholic extract of leaves of Sarcostemma acidum (Roxb.) Voight

Abstract

In the present investigation anxiolytic activity of hydroalcoholic extracts of leaves of Sarcostemma acidum was evaluated. The activity was screened with the adult mice by the light–dark box test, and motor coordination with the rota rod test. The efficacy of the root extract at the dose of 200 and 400 mg/kg was compared with the standard drug diazepam (1 mg/kg i.p.) The results indicate that extract increased the time spent in the brightly-lit chamber of the light/dark box, as well as in the number of times the animal crossed from one compartment to the other.