Antihypertensive activity of Allium sativum and Limmonia acidissima

Abstract

Egg feed-induced hypertensive rat model and Glucose-induced hypertensive rat model leading to increased blood volume and hence increased blood pressure. SBP and DBP were increased persistently in Egg feed-induced hypertensive rat model and Glucose-induced hypertensive rat models as compared to normal rats and Methanolic extract of fruits of allium sativum and limmonia acidissima revealed the presence of alkaloids, because of these compounds the plants shows significant antihypertensive activity. The present study revealed that Methanolic extract of fruits of allium sativum and limmonia acidissima possessed profound antihypertensive activity. As expected Amlodipine shows significant effect against hypertensive rats. Methanolic extract of fruits of allium sativum and limmonia acidissima (100mg/kg) showed good effect as compared to Amlodipine and Methanolic extract of fruits of allium sativum and limmonia acidissima (200mg/kg) showed almost similar effect as Amlodipine.