Stability Indicating RP-HPLC method for simultaneous determination of Aspirin and Omeprazole in the Bulk drug and Synthetic mixture

Abstract

In the present research work, a successful attempt was made for “Validated HPLC method development for the estimation of some drugs in marketed formulation” which was developed by experimentation based on thorough literature survey and ascertained by statistical parameters o fsampling. The simplicity, rapidity, accurate and reproducibility of the proposed methods completely fulfill the objective of the research work of estimation of the drug in marketed formulation. Proposed method was found to be linear in the range of 5-25 μg/ml aspirin and omeprazole with the correlation coefficient near to one respictively. The validation and the reliability of preposed method were assessed by recovery study. The recovery of added standards (80%, 100%, 120%) was ranging from 100.042±0.260 to 100.033±0.208, 99.944±0.428 and 100.08±0.641, 100.26±0.321 to 98.54±0.553 for aspirin and omeprazole respectively.