Protective effect of Syzygium cumini seeds against doxorubicin induced cardiotoxicity in rats

Abstract

Syzygium cumini Linn. seeds possessing potent antioxidant and cardioprotective properties were evaluated against Doxorubicin induced cardiotoxicity in rats. Intra peritoneal injection of DOX(1.5 mg / kg/bw) administered once a day for 15 days, was revealed by elevated serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT), HDL-cholesterol and changed LDL-cholesterol, and triglycerides in comparison to control and associated with increase in the levels of myocardial malondialdehyde (MDA) with simultaneously  decrease in the levels of glutathione (GSH), glutathione-s-transferase(GST),glutathione reductase(GR), glutathione peroxidase (GPx),catalase(CAT) and super oxide dismutase (SOD). Daily oral administration of aqueous suspension of Syzygium cumini seeds extract (in the dose of 100 mg/kg/b.w. for 15 days) produced normalization in the serum levels of heart marker enzymes. Syzygium cumini seeds were found to be more effective in restoring lipid profile changes in rats and antioxidant enzyme activities in heart tissue. So the study shows that Syzygium cumini seeds possess antioxidant and cardioprotective effects.