A review on osmotically regulated devices

Abstract

Osmosis is a physical phenomenon that has been extensively studied by scientist in various disciplines of science and engineering. Osmotic devices are the most promising strategy based system for controlled drug delivery. Convention drug delivery system has little control over their drug release and almost no control over the effective concentration at the targeted site. This kind of dosing pattern may result in constantly changing, unpredictable plasma concentration. Drug can be delivered in a controlled pattern over a long period of time by the process of osmosis. Osmotic pump offers many advantages over other controlled release devices i.e. they are easy to formulated and simple in operation, improve patient compliance with reduced dosing frequency and prolong therapeutic effect with uniform blood concentration. They are the most reliable controlled drug delivery system and could be employed as oral and implantable drug delivery system. Drug delivery from this system is not influenced by the different physiological factor with in the gut lumen and the release characteristics can be predicted easily from the known properties of drug and dosage form. In this paper, various types of osmotically controlled pump with basic component and factor affecting have been discussed briefly.