Analgesic activity of Psidium guajava (L.) fruit extracts effect in mice

Abstract

The unrivalled substitutes to synthetic medicines are available, for
relieving pain and these substitutes are from natural products of plants.
They exhibit variety of activities. The present study evaluated the
analgesic activity of the Aqueous fruit extract of the plant. The Aqueous
extract of the fruits of P. guajava were tested in three pain models viz. to
viz. Eddy’s Hot plate, Tail immersion and Acetic acid induced pain
models in mice. The treatment of P. guajava at varying doses (100
mg/kg and 200 mg/kg) of extract was administered orally by gastric
gavage. It significantly (P<0.05) reduced the pain induced by Hot plate
(74.29%) Tail immersion (76.03%) and Acetic acid induced abdominal
contraction (73.92%) respectively and potency found was equivalent as
compared to standard drug Diclofenac sodium and Pentazocin. The
presence of flavonoids, tanins and saponins in the extract of P. guajava
are responsible for Analgesic effect.