Formulation and Evaluation of Oro-dispersible Tablets of Ondansetron Hydrochloride by Direct Compression Method

Abstract

The main aim of this research paper is to formulate and evaluate Orodispersible tablets of OndasetronHCl by direct compression method. The
oral route of drug administration is that the most vital method for
administering drugs for systemic effects. For rapid dissolution of dosage,
water must rapidly penetrate into the tablet matrix to cause quick
disintegration and instantaneous dissolution may be a fundamental to
formulate ODT. Oro-dispersible tablets of ondansetron hydrochloride are
prepared by direct compression method. The formulation 75% of super
disintegrate (i.e) Starch Glycolate and Cross Povidone, Ac Di Sol &
Microcrystalline Cellulose pH102 has shown best release with 99.46% at
the top of 30 minutes the bubbling mixture further assists in taste
masking of Ondansetron hydrochloride. Consistent with IR studies
there's no incompatibility shown. The formulation found stable at
40°C±2ºC and 75%RH±5%RH.