Protective role of vitamin c against cytotoxicity induced by adriamycin in mice

Abstract

In the present investigation the protective effects of ascorbic acid in adriamycin induced cytotoxicity was evaluated in in vivo animal using analysis of chromosomal aberrations in somatic cells of mice. Three doses of ascorbic acid were selected for modulation and given to animals after priming with adriamycin.  The animals were sacrificed after 24hr., 48 hr. and 72 hr and mitotic preparations were made according to the standard method and slides were prepared. In AA treated animals, the percentage of chromosomal aberrations were found to be in significant. But when perimed along with adriamycin, a significant decrease was observed in the percentage of chromosomal aberrations when animals primed with ascorbic acid. In conclusion our results indicate that vitamin C ameliorated genotoxicity induced by adrianycin in mice somatic in vivo.