Effect of cryoprotectant on lyophlisation of doxorubicin –HCl loaded chitosan nanoparticles

Abstract

Nanoparticles stability of formulation is very poor when it is in form of aqueous suspension. So, Freeze-drying becomes a good technique to improve the stability of colloidal nanoparticles. Shelf life of colloidal particles can be enhanced by lyophilisation by several folds. Cryoprotectants are added during lyophilisation to protect the intactness of particles in injectable products. The present study is aimed at studying the role and influence of type of cryoprotectant and its concentration in the lyophilization of Doxorubicin- HCl Chitosan Nanoparticles.