Formulation and evaluation of naproxen sodium rapimelts by direct compression method

Abstract

Naproxen sodium is an analgesic NSAID (non steroidal anti inflammatory drug) used for the treatment of pain, inflammation, fever and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout, migraine and dysmenorrhea. However, the gastric discomfort caused by drug results in poor patient compliance associated with its conventional dosage forms. Hence the present investigation was undertaken with a view to develop Rapimelt tablet of naproxen, which offers quick onset of action of drug and minimizes the problem of gastric discomfort associated with it. Thus improves patient compliance, generates rapid response, enhances bio-availability and also reduces the dose of drug. In this study, rapimelt tablets were prepared by direct compression method using three different superdisintegrants e.g. sodium starch glycolate, croscarmellose sodium and crospovidone in three different concentrations e.g. 2%, 4% and 6% along with other excipients. The prepared tablets were evaluated for weight variation, hardness, friability, disintegration time, wetting time and dissolution rate. In the present work efforts have been made to prepare and evaluate Rapimelt tablets of Naproxen with different concentrations of superdisintegrants sodium starch glycolate, CCS and Crospovidone by direct compression technique. Release profile of F-9 having 6% Crospovidone in direct compression method was found to have maximum release of 97.56 % at the end of 30 minutes. The drug release from all batches was found to be concentration dependent. Hence the formulation of F-9 fulfills the objective of the present study. of F-12 fulfills the objective of the present study.